Institute for Molecular Bioscience Studying the molecular mechanisms of life, ageing, disease and death The Fairlie Group work at the interface of chemistry and biology to better understand the molecular mechanisms of life, ageing, disease and death.
The chemists within the group study medicinal chemistry, organic synthesis, and computer aided drug design; use nuclear magnetic resonance (NMR) spectroscopy to investigate the structure and dynamics of proteins; and learn how small molecules interact with other small molecules, proteins, RNA and DNA. They discover new chemical structures, reactions and mechanisms; enzyme inhibitors, agonists and antagonists; and molecules that mimic the structures and functions of bioactive protein surfaces. The biologists within the group use these novel compounds to explain the functions of human proteins and cells, and apply them to treat animal models of human diseases. They study mechanisms of protein and cell activation, biological processes, disease development and drug action."They are working, in some cases with industry partners, louis vuitton shoes lock to discover new drugs and treatments for viral and parasite infections, such as HIV, dengue fever and malaria; inflammatory diseases, such as arthritis and inflammatory bowel disease; metabolic and cardiovascular diseases resulting from obesity and type 2 diabetes; cancers; and neurological diseases, such as Alzheimer's and stroke." Their research on diseasesinvolves basic, strategic and applied research top 5 louis vuitton bags in biochemistry, pharmacology and virology. It is directed at understanding: How the immune system resolves infection (byparasites, viruses, bacteria) and tissue injury;How our novel compounds can louis vuitton dog collar amazon act on human proteins, human and rodent cells and tissues, and rat or mouse models of human diseases. understanding how the immune system resolves infection (by parasites, viruses, bacteria) and tissue injuryhow our novel compounds can act on human proteins, human and rodent cells and tissues, and rat or mouse models of human diseases. See links for our publications in all of these disease areas and allied chemical, biochemical and pharmacological research. Chemistry researchers in our group develop expertise in medicinal chemistry and organic chemistry, using solution and solid phase organic synthesis; structure determination through 2D NMR spectroscopy; computer aided drug design; and study interactions between small molecules and proteins, DNA and RNA. Outcomes are new chemical reactions, new chemical mechanisms, new organic compounds, new chemical structures, novel enzyme inhibitors, protein agonists and antagonists, and structural mimics of protein surfaces as new leads to drugs, diagnostics and vaccines. Biology researchers in our group interrogate human and viral proteins and human cell/tissue function, and elucidate mechanisms of protein activation, biological/physiological processes, viral infection, disease development, and drug action. Understanding how molecules interact, how chemical and biological reactions work, and how structure influences activity enables us to design, synthesise and evaluate enzyme inhibitors, receptor antagonists and protein couverture d&agenda louis vuitton binding ligands as new drugs for cancer, infectious diseases, inflammatory disorders, type 2 diabetes, obesity and Alzheimer's disease.
Chemists in our group discover new drugs. Pharmacologists, biochemists and cell biologists in our group study actions on human cells and in animal models of diseases. Traineeships, honours and PhD projects include Drug mechanisms of action (cell biology, signalling pathways, enzymology, GPCRs) Pharmacology (rodent models of inflammatory diseases, metabolic diseases, type 2 diabetes, cancers, Alzheimer's disease).
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